FORMULATION AND EVALUATION OF A CO-DISINTEGRANT MIXTURE IN METRONIDAZOLE TABLET USING QUALITY BY DESIGN APPROACH

Authors

  • H.S. MAHMUD Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria
  • S.O. YAKUBU Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria
  • Y.E. APEJI Department of Pharmaceutics and Industrial Pharmacy, Ahmadu Bello University, Zaria

Keywords:

Khaya senegalensis gum, Optimized, Sammaz maize starch, Superdisintegrant

Abstract

The aim of this study was to assess the disintegrant property of Sammaz Maize starch (MS) and Khaya senegalensis
gum (KG) and the potential effects of mixing the disintegrants to select an optimized concentration for the formulation
of immediate release tablets of metronidazole manufactured via direct compression. Design of Experiments (DoE)
was employed to derive the ratios for the combination and also to optimize the composition using the desirability
function. The optimized formulation contained MS (1.86%) and KG (8.14%) as disintegrant. Tablets were prepared
by direct compression and tablet quality tests were carried out. The formulations produced non-friable tablets
(friability- 0.632-1.07 %) with sufficient hardness of between 3.9-5.4 KgF and displayed rapid disintegration between
7.5 to 11.67 seconds showing a super disintegrant property. The physical combination of MS and KG was found to
be an effective co-disintegrant mixture in immediate release tablets of metronidazole and displayed novel super
disintegrant characteristics.

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Published

2022-06-15

Issue

Vol. 21 No. 1 (2022)

Section

Articles