MANAGEMENT OF ALLOXAN INDUCED DIABETES IN MALE RATS WITH ETHANOL LEAF EXTRACT OF AFRICAN EGG PLANT AND BITTER LEAF SHOWING THEIR EFFECTS ON SOME KIDNEY INDICES

Authors

  • O.A. OYESOLA Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun state
  • I.O. OSONUGA Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun state
  • E.O. TAIWO Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun state
  • E.T. GEORGE Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ogun state
  • A.O. OMOAGHE Department of Physiology, College of Medicine and Health Sciences, Afe Babalola University, Ado- Ekiti, Ekiti state

Keywords:

Blood electrolyte, haematological parameters, kidney histology, antioxidant enzymes.

Abstract

The effects of ethanol leaf extract of African eggplant and bitter leaf plant, as well as their combination, on kidney
histology and antioxidant enzymes activity, as well as selected biochemical and haematological parameters in male
Wistar rats, were studied. The rats were divided into four groups: control group A, diabetic group B, group C treated
with 1000 mg/kg African eggplant, group D treated with 1000 mg/kg bitter leaf, and group E treated with a
combination of 1000 mg/kg African eggplant and bitter leaf. Level of significance set at P< 0.05, and groups C, D,
and E were compared with groups B. Results showed that groups C and D showed improvement in sodium level and
platelets count. Group D showed reduction in potassium level, with no positive changes in urea and creatinine
concentration in groups C, D and E but red blood cell and haematocrit count increased. Group C showed increase in
white blood cell. Groups C and E showed increase in haemoglobin content of the blood. Superoxide dismutase (SOD)
activities and catalase (CAT) activities increased, while Malondialdehyde (MDA) decreased in groups C, D and E
kidney tissue. Kidney histology in groups C and D showed regenerative changes, while group E had positive effect
kidney tissue. The Results of this study showed that extracts were able to improve kidney function and haematological
parameters in diabetic rats.

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Published

2022-06-15

Issue

Vol. 21 No. 1 (2022)

Section

Articles