AQUEOUS EXTRACT OF SOLANUM MACROCARPON LEAVES AMELIORATES DYSLIPIDEMIA, OXIDATIVE STRESS, RENAL HISTOPATHOLOGY AND DYSFUNCTION IN ALLOXAN-INDUCED DIABETES
Keywords:
Antioxidant enzymes, blood electrolyte, diabetes mellitus, histology, lipid profile, Solanum macrocarpon.Abstract
This research investigated the effect of aqueous extract of Solanum macrocarpon leaves on antioxidant enzymes
and histology of the kidney, lipid profile, and blood electrolytes in alloxan-induced diabetic male Wistar rats. For
the study, 30 male Wistar rats weighing between 150 g and 200 g were randomly categorized into six groups of
five rats each. Normal (A) and diabetic control (B) groups were given distilled water. The diabetic treated groups
were given 250 mg/kg, 500 mg/kg, and 750 mg/kg body weight of Solanum macrocarpon orally for 14 days.
Significant reversal of the altered levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein
(LDL) and high-density lipoprotein (HDL) were observed in the results. Amelioration of the altered blood glucose
and electrolyte levels also occurred. The histological study showed damage to the renal tubules of the untreated
rats, which was absent in diabetic rats treated with the aqueous extract. The findings suggest that the aqueous
Solanum macrocarpon leaves extract can be utilized as a source of natural antioxidants with anti-diabetic and
anti-hyperlipidemic potential.