COMPARATIVE IN-VITRO ACTIVITY OF FLUOROQUINOLONES AGAINST CLINICAL BACTERIAL PATHOGENS ISOLATED FROM CENTRAL HOSPITAL WARRI
Keywords:
Anti-Bacterial Agents, Bacterial Infections, Bacteriological Techniques, Fluoroquinolones, Nigeria, Pefloxacin, Urinary Tract Infections.Abstract
Local sensitivity and resistance are important guides to help clinicians to make good choices in a given situation
that demands the use of antimicrobial agents. Antibiotic susceptibility testing was carried on bacterial isolates
from clinical specimens and ascertain their susceptibility to fluoroquinolones and other antimicrobial agents. A
total of 260 clinical samples of urine, Sputum, cerebrospinal fluid, semen, aspirates, and swabs from wound,
virginal, ear, and nose consecutively at the Central Hospital, Warri was examined using standard bacteriological
techniques. Antibiotic susceptibility tests were performed using the standard disc diffusion method. A total of 118
bacterial isolates were recovered. The significant pathogens included Staphylococcus aureus (31.35%), Klebsiella
aerogenes (27.97%), Escherichia coli (22.03%), Pseudomonas aeruginosa (9.30%), Proteus mirabilis. (8.5%)
and Streptococci sp. (0.85%). Overall sensitivity was shown to be pefloxacin 100% while ofloxacin, ceftazidime
and cefuroxime were 83.05% and ciprofloxacin 80.51%, gentamicin 77.12%, streptomycin 34.75%, penicillin
7.6% and ampicillin 2.5% of strains tested. The sensitivity results showed the continued increase in the prevalence
of antibiotic resistance in older penicillin-based B-lactams, penicillin and ampicillin. Also, given the prominent
role of susceptibility in health matters, there is a need to keep physicians current on organisms' sensitivity and
resistance possibilities, as demonstrated by this work.