PRELIMINARY ASSESSMENT OF THE ANTI-NOCICEPTIVE EFFECT OF STERCULIA SETIGERA (MALVACEAE) IN EXPERIMENTAL ANIMALS

Authors

  • O. Edosuyi Dept. of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin
  • L.B. Bealo Dept. of Pharmacology & Toxicology, Faculty of Pharmacy, Igbinedion University Okada
  • A. Pongri Dept. of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin
  • I. Igbe Dept. of Pharmacology & Toxicology, Faculty of Pharmacy, University of Benin

Keywords:

Anti-nociceptive, acute toxicity, hot plate, mouse writhing, Sterculia setigera.

Abstract

Sterculia setigera (Malvaceae) is a deciduous tree commonly found growing in the savannah of tropical Africa. A
decoction of stem bark extract is used to treat headaches. This study aims to investigate the anti-nociceptive activity
of the ethanol extract of S. setigera. The acute study involved the administration of extract at 500, 1000, and 2000
mg/kg to determine the lethal dose (LD50). Anti-nociceptive activity was examined using the mouse writhing and the
hot plate test methods. Acute toxicity studies did not show any sign of mortality at 2000 mg/kg. The stem bark of S.
setigera at 200mg/kg produced a significant (p<0.05) reduction in the number of writhes observed in the writhing
test. However, oral administration of the extract (100, 200, 400 mg/kg) did not prolong (p>0.05) the reaction times
in the hot plate test. This study shows that S. setigera possesses an anti-nociceptive effect.

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Published

2024-03-22

Issue

Vol. 23 No. 1 (2024)

Section

Articles