ASSESSING THE IMPACT OF VARIOUS REGIMENS OF SECOND-LINE ANTIRETROVIRAL THERAPY ON THE QUALITY OF LIFE OF PEOPLE LIVING WITH HIV/AIDS, A SYSTEMATIC REVIEW

Authors

  • Z. Bashir Department of Clinical Pharmacy and Pharmacy Practice, Ahmadu Bello University, Zaria
  • M. A. Zayyad Department of Clinical Pharmacy and Pharmacy Practice, Ahmadu Bello University, Zaria
  • N.M. Danjuma Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria
  • A.A. Biambo Department of Clinical Pharmacy and Pharmacy Practice, Usmanu Danfodiyo University, Sokoto

Keywords:

Antiretroviral therapy, HIV/AIDS, Quality of life, PLHIV, Second-line

Abstract

Antiretroviral therapy (ART) has significantly improved HIV management, but some patients may require second-line
regimens due to treatment failure. This systematic review explores the impact of second-line ART on quality of life
(QoL) among people living with HIV/AIDS (PLHIV). PubMed/MEDLINE, Embase, Cochrane Library, and Google
Scholar were searched for eligible studies, and a total of 597 records were identified. Of the total records identified,
28 articles were removed as duplicates, and 569 articles were subjected to screening. A total of 23 eligible studies
from 2018 to 2022 were analyzed. It was found that various regimens such as TDF+3TC+ATV/r, AZT+3TC+ATV/r
improved the QoL of PLHIV. This was influenced by factors like pill burden, age, gender, and viral load. Tailoring
ART to individual needs is critical to ensure efficacy, simplicity, and improved QoL. In conclusion, the review
highlighted the intricate relationship between various regimens of second-line ART and QoL. These insights aid
clinicians and policymakers in enhancing care for PLHIV, especially in resource-limited settings. Further research on
QoL with second-line ART is vital for better treatment outcomes and public health.

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Published

2024-03-22

Issue

Vol. 23 No. 1 (2024)

Section

Articles