MODULATION OF DOLUTEGRAVIR-INDUCED GEOTACTIC DEFICITS INDROSOPHILA MELANOGASTER BY HEXANE EXTRACT OF BRASSICA OLERACEA

Authors

  • L. Amagon Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos Author
  • K. D. Falang Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos Author
  • B. B. Bukar Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of Jos, Jos Author

Keywords:

Brassica oleracea, Diet, Dolutegravir

Abstract

This study investigated the protective role of Brassica oleracea against dolutegravir-induced effects on geotactic
behavior in Drosophila melanogaster. Conducted at the Africa Center of Excellence in Phytomedicine Research and
Development, University of Jos, flies were exposed to varying concentrations of dolutegravir (0.5–4 mg/5 g diet)
and B. oleracea extract (7.5–1000 mg/5 g diet) for toxicity (LC50 determination) and behavioral assessments. A fiveday exposure to specific extract doses (50–400 mg/5 g diet) was followed by geotaxis assays and
acetylcholinesterase (AChE) activity analysis. B. oleracea extract was non-toxic and improved AChE activity,
negative geotaxis and climbing ability in flies exposed to dolutegravir. These results suggest that the hexane extract
of B. oleracea has modulatory activity against dolutegravir-induced geotactic deficits in Drosophila melanogaster.

Downloads

Published

2025-09-25

Issue

Vol. 24 No. 2 (2025)

Section

Articles