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Journal Of Tropical Biosciences

Year: 2016|   Volume No: 11|   ISSN: 0795-3089|   Page No: 18


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Title:  EFFECT OF CAMEL MILK SUPPLEMENTATION ON SERUM OXIDATIVE STRESS MARKERS IN SALT-INDUCED HYPERTENSIVE RATS

*DANDARE, A. , ISA, S. A., LADAN, M. J., MAINASARA, A. S. AND SAIDU, Y.

DEPARTMENT OF BIOCHEMISTRY, FACULTY OF SCIENCE, USMANU DANFODIYO UNIVERSITY, SOKOTO.

ABSTRACT

Metabolic disorders are a major burden for public health systems globally. Excess generation of highly reactive free radicals causes oxidative stress, which further aggravate the development and progression of hypertension. There is growing evidence that Camel milk could have favourable effects on the attenuation and prevention of metabolic disorders. Therefore, the present study was carried out to investigate the effects of camel milk supplementation on serum oxidative stress markers in salt-induced hypertensive rats. Rats were randomly divided into four groups: Group I: control (normal), Group II: salts induced untreated, Group III: salt-induced supplemented with camel milk, Group IV: salt-induced treated with 100mg/kg Metformin + 10mg/kg Nifedipine. All rats except group I were administered 8% salt-diet for 6 weeks which resulted in hypertension associated with lipid peroxidation as indicated by a significant increase of malonyldialdehyde (MDA). Serum levels of antioxidant vitamins (A, C and E) were depleted in all experimental groups. The activity of antioxidant enzymes glutathione peroxidise (GPx), superoxide dismutase (SOD) and catalase also decreased significantly (P<0.005) in all experimental groups. However, supplementation with camel milk ameliorated the changes in the serum level of MDA, antioxidant vitamins and the activity of antioxidant enzymes. The results suggest that camel milk supplementation could be an effective means of prevention and management of oxidative stress and its related complications.

SUMMARY:

Camel milk supplementation improved the level of antioxidant enzymes and vitamins in

hypertensive rats and may have promising effect in the management and prevention of

hypertension and other oxidative stress related  disorders.

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