Growth and resilience in a knowledge-driven global economy is predicated on a labor force that is healthy and endowed with requisite skills to meet emerging economic realities. The education and health sectors in SSA have over the years remained weak as the volume and capacity of human capital remains unable to meet the challenges of the 21st century or compete favorably in global markets. Therefore, this paper sought to assess the determinants of human capital development in SSA using region-specific regression analysis with a view to identifying the drivers and bottlenecks of human capital development in comparison with other regions (EAP, ECA, LAC, MENA, NA and SSA).This is expected to provide insightful information and lessons regarding human capital development-related policy formulation and implementation. The trend analysis shows that the direction of government priorities and commitments in terms of resources devoted to the education and health sectors have led to the glaring disparities in regional human capital development efforts; with SSA lagging behind. For instance, East Asia committed far more resources and gave high priority to the education and health sector compared to SSA. The impact of those investments have directly culminated to high literacy rates and markedly improved years of life expectancy at birth thus leading to higher output per unit of labour. It was also observed that regions that experienced remarkable human capital development had over the years maintained macroeconomic stability.