ANTIBACTERIAL ACTIVITIES OF SPONDIAS MOMBIN ON CLINICAL ISOLATES FROM UNIVERSITY OF BENIN TEACHING HOSPITAL EDO STATE NIGERIA.

Abstract

Spondias mombin has been reportedly used in the treatment of many diseases in eastern Nigeria by the natives. The
composition of this world-wide cultivated plant and the reported medicinal values prompted this study, which aimed
at evaluating the phytochemical and antibacterial activity of the crude leaf extracts of Spondias mombin. The
antibacterial activity of the n-hexane and the n-butanol leaf extract of Spondias mombin was tested using some selected
clinical isolates using standard agar diffusion and broth dilution method. The phytochemical Screening of the plants
leaves was determined by standard methods. Phytoconstituents was present in both n-hexane and n-butanol solvent
extracts which includes; saponins, alkaloids, carbohydrate, steroids, glycosides and tannins, the n-hexane and n-
butanol extract showed increased activity (as concentration increases, activity increases and decrease in concentration
leads to reduction in activity) against both clinical and standard strains with the exception of E. coli. in n-hexane leaf
extract. Good activity was demonstrated by CPR (10μl), OFL(5μl) and GENT(5μl). Both solvents extract and
gentamicin demonstrated high MIC and MBC values. The results demonstrate that the plant leaves have medicinal
properties, hence, its trad-medical usage.